Myocardial ischemia-reperfusion injury case study

Myocardial ischemia-reperfusion injury is tissue damage caused by blood supply returning to the tissue after a heart attack.

The purpose of this case study is to detail the standard workflow of a modeling & simulation project. Applied to myocardial reperfusion injury this in silico clinical trial shows the efficacy of the inhibition of reactive oxygen species production in ST elevated myocardial infarction.


  1. What is myocardial reperfusion injury?
  2. Model development
  3. Validation and simulations
  4. Optimal regimen
  5. Responders characterization

case study

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