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Poster
ACOP 23, Oct 31, 2024
A multiscale model of atherosclerotic cardiovascular disease to predict lipid lowering therapies effect on clinical events
S. Porte, E. Courcelles, E. Peyronnet, Y. Wang, P. Amarenco, D. Angoulvant, F. Boccara, B. Cariou, G. Mahé, P.G. Steg, A. Bastien, L. Portal, L. Bruziere, E. Bechet, S. Granjeon-Noriot
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Publication
ISPOR-Europe23, Oct 31, 2024
In Silico Clinical Trials Using Mechanistic Knowledge-Based Model, an Innovative Approach to Accelerate Data Generation and Support Health Technology Assessment
E. Pham, S. Porte, E. Courcelles, E. Peyronnet, Y. Wang, A. Diatchenko, G.Gomez, P. Amarenco, D. Angoulvant, F. Boccara, B. Cariou, G. Mahé, N. Marquet, A. Bastien, L. Portal, JP. Boissel, E. Bechet, S. Granjeon-Noriot, P.G. Steg
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Poster
ACC 2024, Oct 31, 2024
Validation of an in-silico knowledge-based mechanistic model of atherosclerotic cardiovascular disease for the SIRIUS study
D. Angoulvant, P. Amarenco, A. Bastien, E. Bechet, F. Boccara, JP Boissel, B. Cariou, E. Courcelles, A. Diatchenko, S. Granjeon-Noriot, G. Mahé, E. Peyronnet, L. Portal, S. Porte, Y. Wang, P.G Steg
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Poster
EAS 2024, Oct 31, 2024
Predicting the efficacy of Inclisiran on cardiovascular outcomes in patients with established atherosclerotic cardiovascular disease: primary results of the in silico SIRIUS trial
D. Angoulvant, P.Amarenco, A.Bastien, E. Bechet, F. Boccara, JP. Boissel, B. Cariou, E. Courcelles, A. Diatchenko, A. Filipovics, S. Granjeon-Noriot, R. Kahoul, G. Mahé, E. Peyronnet, L. Portal, S. Porte, Y. Wang, P.G. Steg
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Poster
ASCO2024, Jun 07, 2024
Prospective validation of in silico clinical trials prediction using an EGFR-mutated NSCLC mechanistic computational disease model
M. Duruisseaux, P. Masson, A. Nativel, N. Girard, J. Cadranel, A. Swalduz, M. Coudron, G. Bouchard, R. Kahoul, E. Jacob, J. Bosley, JL. Palgen, A. L'Hostis, C. Monteiro
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Publication
jacionline (february 16, 2024) DOI:https://doi.org/10.1016/j.jaci.2023.12.031, May 31, 2024
A quantitative systems pharmacology workflow toward optimal design and biomarker stratification of atopic dermatitis clinical trials
Natacha Go, Simon Arsène, Igor Faddeenkov, Théo Galland, Shiny Martis B., Diane Lefaudeux, Yishu Wang, Loic Etheve, Evgueni Jacob, Claudio Monteiro, Jim Bosley, Caterina Sansone, Christian Pasquali, Lorenz Lehr, Alexander Kulesza,
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Publication
MDPI Biomedicines 2024 (21 March 2024) 12(3), 704; https://doi.org/10.3390/biomedicines12030704, May 31, 2024
Comparing the Efficacy of Two Generations of EGFR-TKIs: An Integrated Drug–Disease Mechanistic Model Approach in EGFR-Mutated Lung Adenocarcinoma
by Hippolyte Darré, Perrine Masson, Arnaud Nativel, Laura Villain, Diane Lefaudeux, Claire Couty, Bastien Martin, Evgueni Jacob, Michaël Duruisseaux, Jean-Louis Palgen, Claudio Monteiro and Adèle L’Hostis
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Publication
BMC Bioinformatics 24, no. 1 (September 4, 2023). https://doi.org/10.1186/s12859-023-05430-w, Sep 11, 2023
Empirical methods for the validation of time-to-event mathematical models taking into account uncertainty and variability: application to EGFR + lung adenocarcinoma
Evgueni Jacob, Angélique Perrillat-Mercerot, Jean-Louis Palgen, Adèle L’Hostis, Nicoletta Ceres, Jean-Pierre Boissel, Jim Bosley, Claudio Monteiro, Riad Kahoul
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Publication
Nature: npj Syst Biol Appl 9, 37 (2023). https://doi.org/10.1038/s41540-023-00292-7, Sep 11, 2023
Knowledge-based mechanistic modeling accurately predicts disease progression with gefitinib in EGFR-mutant lung adenocarcinoma
Adèle L’Hostis, Jean-Louis Palgen, Angélique Perrillat-Mercerot, Emmanuel Peyronnet, Evgueni Jacob, James Bosley, Michaël Duruisseaux, Raphaël Toueg, Lucile Lefèvre, Riad Kahoul, Nicoletta Ceres, Claudio Monteiro
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Poster
ESC Congress 2023, Aug 25, 2023
Design of a knowledge-based mechanistic model of atherosclerotic cardiovascular disease for in silico trials
D. Angoulvant1, P. Amarenco2, A. Bastien3, E. Bechet4, F. Boccara5, JP. Boissel4, B. Cariou6, E. Courcelles4, S. Granjeon-Noriot4, G. Mahé7, E. Peyronnet4, L. Portal3, S. Porte4, Y. Wang4, P.G. Steg8
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Poster
AACR 2023, May 11, 2023
Exploring the impact of assuming spherical tumors on the modeled clinical outcome through the analysis of tumor measurements and in silico simulations
J. Kleine-Schultjann1, G. Gómez1, A. L'Hostis1, J-L. Palgen1, C. Monteiro1, P. Masson1
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Poster
AACR 2023, May 11, 2023
The combination of statistical methods to compare observed and simulated data allowed to assess effectively the validity of mathematical model predictions in a context of a EGFR+ Lung Adenocarcinoma
Evgueni Jacob1, Laura Villain1, Nicoletta Ceres1, Jean-Louis Palgen1, Adèle L'Hostis1, Claudio Monteiro1, Riad Kahoul1
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Poster
AACR 2023, May 11, 2023
Simulations of tumor heterogeneity impact on treatment response using a mechanistic model of EGFR-mutant lung adenocarcinoma
P Masson1, C Couty1, A Nativel1, E Jacob1, R Toueg2, M Duruisseaux3, A L’Hostis1, JL Palgen1, C Monteiro1
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Poster
AACR 2023, May 11, 2023
Comparison of the effect of two EGFR-TKI in patients with EGFR-mutant lung adenocarcinoma using in silico clinical trials
H. Darré1, B. Martin1, F. Hammami1, A. Nativel1, D. Lefaudeux1, R. Toueg2, M. Duruisseaux3, J-L. Palgen1, P. Masson1, A. L’Hostis1, N. Ceres1, C. Monteiro1
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Poster
ASCPT 2023, Apr 05, 2023
Effectiveness of high dose versus standard dose influenza vaccines in older adults : insights from a multi-strain modeling approach
Urdy, S.; Ratto, N.; Hanke, M.; Toledo, A. I.; Peyronnet, E.; Jacob, E.; Thommes, E.; Chaves, S.; Coudeville, L.; Boissel, J. P.; Bruezière, L. and Courcelles, E.
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Poster
4th European Conference on Pharmaceutics, Mar 28, 2023
Characterization of optimal clinical trial design and best responders characteristics using mechanistic modeling Application to Chronic HBV
Solène Granjeon-Noriot, Anne Schneider, Solène Porte, Emmanuel Peyronnet, Pietro Scalfaro, Emmanuel Pham, Lara Bruezière
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Publication
NATURE REVIEWS, Oct 07, 2022
Predictive validity in drug discovery: what it is, why it matters and how to improve it
Jack W. Scannell, James Bosley, John A.Hickman, Gerard R. Dawson, Hubert Truebel, Guilherme S. Ferreira, Duncan Richards and J.Mark Treherne
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Poster
VPH Conference, Sep 09, 2022
Integration of heterogeneous biological data in multiscale mechanistic model calibration
Jean-Louis Palgen, Angélique Perrillat-Mercerot, Nicoletta Ceres, Emmanuel Peyronnet, Matthieu Coudron, Jim Bosley, Adèle L'Hostis, Claudio Monteiro
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Poster
VPH Conference, Sep 09, 2022
Building a cloud simulation system for reproducible and multi-level cached in-silico trials
Eliott Tixier, Matthieu Coudron, Yves Parès
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Poster
ERS Conference, Sep 06, 2022
Viral kinetic modeling and simulation of the impact of non-pharmaceutical COVID-19 interventions in different countries: model-informed respiratory disease trial design
Igor Faddeenkov, Simon Arsène, Alexander Kulesza
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Publication
Acta Biotheoretica, Jul 07, 2022
Integration of Heterogeneous Biological Data in Multiscale Mechanistic Model Calibration: Application to Lung Adenocarcinoma
Jean‑Louis Palgen, Angélique, Perrillat‑Mercerot, Nicoletta Ceres, Emmanuel Peyronnet, Matthieu Coudron, Eliott Tixier, Ben M. W. Illigens, Jim Bosley, Adèle L’Hostis, Claudio Monteiro
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Poster
EAACI 2022, Jul 01, 2022
A mechanistic skin immunology model for the support of atopic dermatitis clinical trial design and biomarker programs
Théo Galland, Igor Faddeenkov, Simon Arsène, Alexander Kulesza
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Poster
QSPC 2022, Apr 21, 2022
Viral kinetic modeling and clinical trial simulation predicts disruption of respiratory disease trials by non-pharmaceutical COVID-19 interventions
Simon Arsène, Alexander Kulesza, Igor Faddeenkov, Théo Galland, Cristhyne Leon
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Poster
QSPC 2022, Apr 20, 2022
A PBPK and immunogenicity model integrated into two disease models
Simon Arsène, Alexander Kulesza, Igor Faddeenkov, Théo Galland, Cristhyne Leon
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Publication
Nature communications, Apr 13, 2022
Modeling the disruption of respiratory disease clinical trials by non-pharmaceutical COVID-19 interventions
Simon Arsène , Claire Couty , Igor Faddeenkov , Natacha Go , Solène Granjeon-Noriot , Daniel Smit , Riad Kahoul , Ben Illigens , Jean-Pierre Boissel , Aude Chevalier , Lorenz Lehr , Christian Pasquali
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Poster
AACR 2022, Apr 12, 2022
Multiscale EGFR mutated NSCLC tumor heterogeneity knowledge-based model predicts tumor growth under Gefitinib: an avenue to in silico clinical trial
M. Duruisseaux1, J-L. Palgen, A. Perrillat-Mercerot, N. Ceres, E. Peyronnet, E. Jacob, R. Kahoul, M. Coudron, M. Poiré, L. Lefevre, R. Toueg, J. Bosley, A. L’Hostis, C. Monteiro
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Publication
Frontiers in Systems Biology: Multiscale Modeling , Mar 07, 2022
Model integration in computational Biology: the Role of reproducibility, credibility and utility
Jonathan Karr, Rahuman S. Malik-Sheriff, James Osborne, Gilberto Gonzalez-Parra, Eric Forgoston, Ruth Bowness, Yaling Liu, Robin Thompson, Winston Garira, Jacob Barhak, John Rice, Marcella Torres, Hana M. Dobrovolny, Tingting Tang, William Waites, James A. Glazier, James R. Faeder and Alexander Kulesza
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Poster
EAACI 2021, Nov 15, 2021
Model based meta-analysis of the effect of non-specific immunomodulation with OM-85 for recurrent viral respiratory tract infections and wheezing: a multi-scale mechanistic approach
Simon Arsène, Alexander Kulesza
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Poster
EAACI 2021, Nov 15, 2021
Application of a mechanistic model to forecast RTI prophylaxis trial feasibility in the post-COVID era
Igor Faddeenkov, Simon Arsène, Alexander Kulesza
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Poster
AASLD conference 2021, Nov 12, 2021
Mechanistic modeling to optimize phase 2b clinical trial design of a new combination therapy for chronic HBV
Solène Granjeon-Noriot1, Anne Schneider1, Emmanuel Peyronnet1, Eulalie Courcelles1, Claire Couty1, Bastien Martin1, Simon Arsène1, Hippolyte Darré1, Evgueni Jacob1, Riad Kahoul1, Hugo Girma2, Marion Odoul2, Isabelle Martin2, Laurène Meyniel-Schicklin2, Dr. Pietro Scalfaro2, Dr. Ben Illigens1,3 and Lara Bruezière1.
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Poster
Iboman 2021, Oct 25, 2021
Application of knowledge-based mechanistic modeling to optimize phase III clinical trials of targeted therapy
A. L’Hostis1, J-L. Palgen1, N. Ceres1, A. Perrillat-Mercerot1, E. Jacob1, R. Kahoul1, M. Coudron1, G. Bouchard1, B.M.W. Illigens1,2, M. Hommel1, J.P. Boissel1, J. Bosley1, C. Monteiro1
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Publication
PLOS One, Oct 11, 2021
Using numerical modeling and simulation to assess the ethical burden in clinical trials and how it relates to the proportion of responders in a trial sample
Jean-Pierre Boissel ,David Pérol ,Hervé Décousus ,Ingrid Klingmann ,Marc Hommel
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Publication
PLOS One, Oct 11, 2021
Using numerical modeling and simulation to assess the ethical burden in clinical trials and how it relates to the proportion of responders in a trial sample
Boissel JP, Pérol D, Décousus H, Klingmann I, Hommel M
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Poster
IASLC WCLC 2021, Sep 08, 2021
Multiscale NSCLC tumor growth knowledge based model reproduces tumor non progression under Gefitinib
Adèle L'Hostis, J.-L. Palgen, N. Ceres, E. Peyronnet, A. Perrillat-Mercerot, A. Schneider, M. Margreiter, E. Jacob
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Poster
IASLC WCLC 2021, Sep 08, 2021
Use of a multiscale NSCLC tumor heterogeneity model to predict tumor growth under Gefitinib
Adèle L'Hostis, J.-L. Palgen, N. Ceres, E. Peyronnet, A. Perrillat-Mercerot, A. Schneider, M. Margreiter, E. Jacob
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Poster
ERS 2021, Sep 05, 2021
Mechanistic model based meta-analysis for paediatric respiratory tract infection prophylaxis trial design
Alexander Kulesza, Simon Arsène, Jean-Pierre Boissel
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Poster
PAGE 2021, Aug 18, 2021
In silico clinical trial simulation shows amelioration of ischemia-reperfusion injury in ST-elevation myocardial infarction via inhibition of reactive oxygen species production
B. Martin, E. Courcelles, A. L’Hostis, L. Etheve, E. Bechet, N. Ceres, E. Jacob, E. Peyronnet, B. M.W. Illigens, M. Hommel, J.P. Boissel
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Publication
IEEE Journal of Biomedical and Health Informatics, Jun 23, 2021
Possible contexts of use for in silico trials methodologies: a consensus- based review
Marco Viceconti, Luca Emili, Payman Afshari, Eulalie Courcelles, Cristina Curreli, Nele Famaey, Liesbet Geris, Marc Horner, Maria Cristina Jori, Alexander Kulesza, Axel Loewe, Michael Neidlin, Markus Reiterer, Cecile F. Rousseau, Giulia Russo, Simon J. Sonntag, Emmanuelle M. Voisin, and Francesco Pappalardo
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Publication
CPT: Pharmacometrics & Systems Pharmacology, Jun 08, 2021
Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: building model credibility
Flora T. Musuamba, Ine Skottheim Rusten, Raphaëlle Lesage, Giulia Russo, Roberta Bursi, Luca Emili, Gaby Wangorsch, Efthymios Manolis, Kristin E. Karlsson, Alexander Kulesza, Eulalie Courcelles, Jean-Pierre Boissel, Cécile F. Rousseau, Emmanuelle M. Voisin, Rossana Alessandrello, Nuno Curado, Enrico Dall’ara, Blanca Rodriguez, Francesco Pappalardo, Liesbet Geris
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Publication
Frontiers in Medical Technology: Regulatory Affairs, Feb 24, 2021
Solving the evidence interpretability crisis in health technology assessment: a role for mechanistic models?
Eulalie Courcelles, Jean-Pierre Boissel, Jacques Massol, Ingrid Klingmann, Riad Kahoul, Marc Hommel, Emmanuel Pham and Alexander Kulesza
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Poster
BioSB2020, Oct 27, 2020
In silico clinical trial shows the efficacy of the inhibition of reactive oxygen species production in ST elevated myocardial infarction
Emmanuel Peyronnet; Eulalie Courcelles; Bastien Martin
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Publication
CPT: Pharmacometrics & Systems Pharmacology, Apr 01, 2020
Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges.
Flora T. Musuamba Roberta Bursi Efthymios Manolis Kristin Karlsson Alexander Kulesza Eulalie Courcelles Jean‐Pierre Boissel Raphaëlle Lesage Cécile Crozatier Emmanuelle M. Voisin Cécile F. Rousseau Thierry Marchal Rossana Alessandrello and Liesbet Geris.
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Poster
AASLD 2019, Nov 08, 2019
An in silico disease model for the development of FXR agonist EYP001 as a therapy for HBV infection
Claudio Monteiro, Lara Bruezière, Samuel Laheux, Marc Hommel, Pauline Radreau, Elise Roy, Raphaël Darteil, Patrice André, Jean-Pierre Boissel, Jacky Vonderscher and Pietro Scalfaro.
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