Discover nova’s Synthetic Control Arms

External Control Arms (ECA) address some of the practical, ethical and cost challenges of recruiting in-trial randomized control arms. Yet ECAs have their own limitations. Mechanistic modeling, such as the modeling developed at Novadiscovery , can create more robust ECAs that overcome these limitations and provide deeper insights into treatment effects at both the population and individual patient level.


  1. Limitations of RWD current approach
  2. Nova’s Synthetic Control Arms
  3. Beyond SCAs : intra-patients controls

white paper

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